Effect of NWT-03 on Blood Pressure - Part 1

Inclusion Criteria: * Be able to give written informed consent, * Be between 35 and 75 years of age, * Be in generally good health as determined by the investigator, * Smokers and non-smokers are eligible, * Have a stable body weight (\< 5% change) over the past 3-months, * Have a Body Mass Index (BMI) between 25 and 35 kg/m2, * Be: (a) Normotensive (Systolic Blood Pressure \<130 mmHg \& Diastolic Blood Pressure \<85 mmHg), (b) High normotensive (Systolic Blood Pressure 130-139 mmHg \& Diastolic Blood Pressure 85-89 mmHg) or (c) Mild hypertensive (Systolic Blood Pressure 140-159 mmHg \& Diastolic Blood Pressure 90-99 mmHg). Exclusion Criteria: * Are less than 35 and greater than 75 years of age, * Females are pregnant, lactating or wish to become pregnant during the study. * Are hypersensitive to any of the components of the test product, * Have a significant acute or chronic coexisting illness such as cardiovascular disease, Chronic kidney disease (CKD), gastrointestinal disorder, endocrinological disorder, immunological disorder, metabolic disease or any condition which contraindicates, in the investigators judgement, entry to the study, * Having a condition or have taken a medication that the investigator believes would interfere with the objectives of the study, pose a safety risk or confound the interpretation of the study results; to include diuretics, blood pressure medication and medication interfering with renin-angiotensin-aldosterone system (RAAS), such as ACE-inhibitors, angiotensin receptor blockers, direct renin inhibitors or aldosterone receptor inhibitor, * Are taking non-steroidal anti-inflammatory drugs (NSAIDs) within 2 weeks of baseline visit or for the duration of the trial, * Suffer from diabetes mellitus, either type I and type II, * Consume more than the recommended alcohol guidelines i.e. \>21 alcohol units/week for males and \>14 units/week for females, * History of illicit drug use, * Use of nasal decongestants and other over-the counter or herbal preparation within 2 weeks of baseline visit and for the duration of the trial, * Heavy intake of coffee (i.e. more that 4 cups daily) within 2 weeks of baseline visit and for the duration of the trial, * Individuals who, in the opinion of the investigator, are considered to be poor attendees or unlikely for any reason to be able to comply with the trial, * Subjects may not be receiving treatment involving experimental drugs, * If the subject has been in a recent experimental trial, these must have been completed not less than 60 days prior to this study. An exception will be made where subjects have participated in part 1 of the study, * Have a malignant disease or any concomitant end-stage organ disease,