Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary Syndrome

West China Hospital64 enrolled

Overview

To prospectively investigate the effect of transjugular intrahepatic portosystemic shunt (TIPS) on oxygenation in cirrhotic patients with hepatopulmonary syndrome (HPS).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hepatopulmonary Syndrome

Interventions

Transjugular intrahepatic portosystemic shuntPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of cirrhosis * Alveolar-arterial oxygen gradient ≥ 15 mm Hg (≥ 20 mm Hg for age \> 64 years) * Positive contrast-enhanced echocardiography Exclusion Criteria: * Age of less than 18 years * Intrinsic cardiopulmonary disease * Malignancy * Active infection * Pregnancy * Previous shunt therapy * Refusal to participate

Locations (1)

West China Hospital, Sichuan university

Chengdu, Sichuan, China

Outcomes

Primary Outcomes

Alveolar-arterial oxygen gradient (PA-a,O2)

Time frame: 12 Weeks

Secondary Outcomes

Macroaggregated albumin (MAA) shunt fraction

Time frame: 12 Weeks

Exhaled nitric oxide (eNO)

Time frame: 12 Weeks

Data from ClinicalTrials.gov

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