Immune Responses to the Flu Shot During Pregnancy

Lisa Christian287 enrolled

Overview

This study will examine effects of everyday life stress and obesity on immune responses to influenza virus vaccine (the flu shot) during pregnancy. Following vaccination, antibody levels against influenza (the flu) increase. Higher antibody levels indicate better immune protection from influenza. In addition to providing protection from the flu for yourself, being vaccinated during pregnancy may protect your baby from the flu during the first six months of life during which time infants cannot be vaccinated. Our primary goals are to determine whether greater life stress and obesity reduce 1) antibody responses to the flu shot in women and 2) antibody levels in the newborn at the time of delivery.

Study Type

OBSERVATIONAL

Enrollment

287

Conditions

Pregnancy

Interventions

influenza virus vaccinationBIOLOGICAL

comparison of immune responses to the flu vaccine in obese and non-obese populations

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * less than 29 weeks pregnant * ages 18-42 * planning to deliver at The Ohio State University Wexner Medical Center Exclusion Criteria: * prior serious adverse reaction to seasonal influenza vaccine

Locations (1)

The Ohio State University Wexner Medical Center

Columbus, Ohio, United States

Outcomes

Primary Outcomes

Maternal HAI Antibody Titers

Maternal influenza antibody titers from hemagglutination inhibition (HAI) assay

Time frame: 30-days after influenza vaccination

Maternal HAI Antibody Titers

Maternal influenza antibody titers from hemagglutination inhibition (HAI) assay

Time frame: at delivery

Secondary Outcomes

Infant HAI Antibody Titers

Infant influenza antibody titers from hemagglutination inhibition (HAI) assay

Time frame: cord blood at delivery

Data from ClinicalTrials.gov

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