Remote Ischemic Preconditioning With Postconditioning in Heart Transplantation Surgery

Chinese Academy of Medical Sciences, Fuwai Hospital60 enrolled

Overview

The purpose of this study is to determine whether remote ischemic preconditioning with postconditioning (RIPC+RIPostC) reduces myocardial injury and improves clinical outcomes in heart transplantation surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Myocardial Ischemic Reperfusion Injury End Stage Heart Disease Heart Failure Cardiomyopathy

Interventions

RIPC+RIPostCPROCEDURE

Four 5 min cycles of upper limb ischemia and reperfusion by a cuff inflated to 200 mmHg, twice (after anesthesia induction and before surgery started, at 20min after aortic declamping)

controlPROCEDURE

a deflated cuff placed on the right upper arm

Eligibility

Sex: ALLMin age: 14 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * scheduled for elective orthotopic heart transplantation surgery Exclusion Criteria: * peripheral vascular disease affecting the upper arms * mechanical circulatory support before surgery * taking the antidiabetic sulphonylurea, glibenclamide * cold ischemic time of donor heart \> 12 hours * repeated heart surgery

Locations (1)

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, CAMS and PUMC

Beijing, China

Outcomes

Primary Outcomes

serum cardiac troponin I (cTnI)

Time frame: within 72 hours after aortic declamping

Secondary Outcomes

plasma microRNA-133b (miR-133b)

Time frame: within 72 hours after aortic declamping

plasma microRNA-208a (miR-208a)

Time frame: within 72 hours after aortic declamping

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.