A total of 384 patients suffering from chronic depressive disorder will be randomized to receive treatment as usual, CBASP, or befriending for a period of five months. The primary outcome is change in Montgomery-Åsberg Depression Scale. Secondary outcomes include changes in self-reported psychiatric symptoms, biomarkers determined from venous blood samples, and neurophysiological parameters. The data gathering is performed at pre- and post intervention stages (i.e., at baseline and at five months). A follow-up questionnaire is sent to the participants six months after the intervention.
The efficacy of 20-week group-CBASP as compared to TAU is evaluated by RCT in a psychiatric outpatient clinics. The recruition is completed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
82
Cognitive behavioral group intervention for individuals suffering from chronic depression
Social support intervention, sessions once per week
Conventional psychiatric outpatient treatment (individual counseling)
University of Eastern Finland
Kuopio, Northern Savonia, Finland
Depression
Montgomery-Åsberg Depression Rating Scale
Time frame: At baseline and after intervention (at 5 months)
Peripheral blood biomarkers
Blood samples are collected before and after intervention.
Time frame: At baseline and after intervention (at 5 mos)
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