Oxygen Therapy in Depression

Meir Medical Center200 enrolled

Overview

The major objective of the present study is to examine the influence of normobaric hyperoxia treatment on the symptoms of patients diagnosed with depression members of Clalit Health Services. The investigators hypothesize that normobaric hyperoxia treatment will improve the symptoms of patients with depression.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

200

Conditions

Depression, Normobaric Hyperoxia.

Interventions

oxygen-enriched air -Normobaric hyperoxia treatment for depressionDEVICE

Forty percent oxygen or regular air will be supplied from oxygen concentrators, through standard plastic nasal prongs, at a flow rate of 5 liters/minute, for 7 hours a day, throughout the night.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women aged 18-65 years diagnosed with mild to moderate depression. Exclusion Criteria: * Patients with oxygen saturation below 95%; * An unstable mental (psychiatric) condition * A psychiatric condition that requires a change in pharmacotherapy (importantly - medications will not be changed in patients who will be enrolled to the study) * Acute or chronic respiratory disease * Any severe physical illness * Suicidal thoughts or attempts * Drug abuse * Obesity (BMI over 30) * Inability to cease smoking during night hours while participants are supposed to be using the oxygen/air supplementing machine.

Locations (1)

Clalit Health Services in the Southern region

Beersheba, Israel

RECRUITING

Outcomes

Primary Outcomes

Hamilton Rating Scale for Depression (HRSD)-changes in patients' depression.

HRSD will be used to assess changes in patients' condition. Assessment will be performed at 3 time points: baseline (time zero), 2 weeks and 4 weeks after treatment initiation, by a trained psychiatric nurse blind to the patient's treatment status.

Time frame: Baseline (time zero), 2 weeks and 4 weeks

Data from ClinicalTrials.gov

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