The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide

Yonsei University50 enrolled

Overview

Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response. Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane. To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well. Secondarily, kidney protection effect of propofol over desflurane will be compared.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Prostate Cancer

Interventions

Eligibility

Sex: MALEMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing robot-assisted laparoscopic radical prostatectomy under general anesthesia Exclusion Criteria: * chronic renal failure ( estimated glomerular filtration rate \<60 mL/min/1.73m2) * allergy to propofol, nuts * on diuretics, vitamin C or vitamin E within 5 days before surgery * Body mass index \> 30 kg/m2 * older than 70 years * who cannot read the patient consent form

Outcomes

Primary Outcomes

changes of serum malondialdehyde, Interleukin-1β, interleukin-6, tumor necrotic factor-α, nitric oxide during operation

Time frame: 100 min after pneumoperitoneum, 10 min after decompression

Secondary Outcomes

kidney function after anesthesia

measure creatinine

Time frame: 1 day after operation