Dose-escalation Trial of Anti-C5aR Antibody in Healthy Subjects

Inclusion Criteria: * Informed consent obtained before any trial-related activities (Trial-related activities are any procedure that would not have been performed during normal management of the subject) * Body weight (BW) below or equal to 110.0 kg * Body Mass Index (BMI) 20.0 - 27.0 kg/m\^2, both inclusive * Good state of health: evidenced by medical history, physical examination and results of laboratory examinations Exclusion Criteria: * History of known or suspected cardiovascular diseases including: supine systolic blood pressure (BP) above or equal to 140 mmHg or below 90 mm Hg, diastolic BP above oe equal to 90 mm Hg or below 40 mm Hg, heart rate (HR) in supine position above 100 beats/minute or below 45 beats/minute * Hepatic insufficiency: Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) above Upper Limit of Normal (ULN) (retesting is permitted within one week if first test is elevated but below 1.5 fold ULN) * Renal insufficiency: Serum creatinine above ULN * Positive for humane immunodeficiency virus (HIV) (by test) * Positive for hepatitis B (HBV) or hepatitis C (HCV) (by test)