Exercise and Weight Control

USDA Grand Forks Human Nutrition Research Center29 enrolled

Overview

The purpose of this study is to research the effects of exercise on calories eaten and expended. The investigator expects to find out whether subjects change their eating and activity behaviors when starting an exercise program.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Overweight Obese

Interventions

Exercise Energy Expenditure 300 kcal/dayOTHER

Exercise Energy Expenditure 600 kcal/dayOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 to 40 years old * BMI of 25.0 - 35 kg/m2 * willing to consent to study conditions * not taking medications that affects energy expenditure or eating * not using tobacco or nicotine products * no food allergies or limitations to eating certain food that would prohibit them from eating the study foods * not be dieting to lose weight * no major health problems * cannot have known cardiovascular, pulmonary or metabolic disease * cannot be regularly exercising in an aerobic manner more than twice per week * must have a liking of at least 5 out of 10 for 75% of the study foods Exclusion Criteria: * \< 18 or \> 40 years old * BMI \< 25 or \>35 kg/m2 * currently pregnant or trying to become pregnant, or lactating * currently using tobacco or nicotine * taking medication that affects energy expenditure or eating * food allergies to foods used in the study * regularly exercising in an aerobic manner more than twice per week * major health problems

Locations (1)

USDA Grand Forks Human Nutrition Reserach Center

Grand Forks, North Dakota, United States

Outcomes

Primary Outcomes

Negative Energy Balance as assessed by changes in adipose tissue

Whether participants were able to maintain a negative energy balance will be assessed by pre-post changes in stored adipose tissue, as assessed by a dual-energy x-ray absorptiometry scan (DEXA).

Time frame: End Training (weeks 10-12)

Secondary Outcomes

Change in relative reinforcing value (RRV) of food

RRV of food will be assessed by evaluating the number of responses (mouse button presses) a participant is willing to complete to gain access to food or an alternative sedentary activity.

Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)

Average daily calories consumed as assessed by dietary recall

On two weekdays and one weekend day, participants will fill out the Automated Self-Administered 24-Hour Dietary Recall (ASA24) to estimate dietary intake (total energy, grams carbohydrates, fat, protein, alcohol).

Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)

Pre-post intervention changes in Ghrelin plasma levels

Participants will provide a fasting blood sample collected in ethylenediaminetetraacetic acid (EDTA)-coated and serum tubes. Changes in acylated Ghrelin will be measured via enzyme-linked immunosorbent assay (ELISA).

Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)

Pre-post intervention changes in glucagon-like peptide 1 (GLP-1) plasma levels

Participants will provide a fasting blood sample collected in EDTA-coated and serum tubes. Changes in GLP-1 concentrations will be measured via ELISA.

Time frame: Pre-intervention (week 0) and End Training (weeks 10-12)

Pre-post intervention changes in Ghrelin concentrations

Data from ClinicalTrials.gov

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