iPod Games in Hepatic Encephalopathy

N/ACompletedNCT02154282

Hunter Holmes Mcguire Veteran Affairs Medical Center30 enrolled

Overview

To see if using ipod games can improve mental functioning

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hepatic Encephalopathy Cirrhosis

Interventions

ipod gamesBEHAVIORAL

Patients will be given ipod games for 4 weeks and tested in related and unrelated cognitive measures

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cirrhosis proven by biopsy, radiology or endoscopy * Age 18-70 * Able to give informed consent * Cognitive dysfunction defined by impaired performance on standard cognitive tests Exclusion Criteria: * Illicit drug or alcohol use within 3 months * Trans-jugular intra-hepatic porto-systemic shunt (TIPS) placement * Need for psychoactive medications apart from continuous anti-depressants or methadone * Any focal neurological deficit or neuro-muscular disease * Inability to function with an iPod * Inability to understand English For MRI: inability to perform brain MRI is an exclusion

Locations (1)

Hunter Holmes McGuire VA Medical Center

Richmond, Virginia, United States

Outcomes

Primary Outcomes

Improvement in cognitive test performance with iPod games

improvement in cognitive performance on a battery of cognitive tests (Psychometric Hepatic Encephalopathy Score, Inhibitory Control test and Verbal Learning) after iPod tests

Time frame: 8 weeks

Secondary Outcomes

Improvement in health-related quality of life

Sickness Impact Profile will be used before and after the treatment

Time frame: 8 weeks

Improvement in brain MRI parameters

change in detailed imaging parameters related to diffusion tensor imaging, resting state and voxel-based morphometry

Time frame: 4 weeks

Data from ClinicalTrials.gov

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