The main objective is to assess the psychological impact of pre-emptive kidney transplantation on patients' quality of life taking into account psychological adjustment (response shift), compared to patients who have experienced a short pre-transplant dialysis period of less than 36 months.
The following outcomes will also be compared between Patients with Pre-emptive Transplantation and Patients with Dialysis before Transplantation : a) changes in quality of life, subjective well-being, perceived anxiety and depressive disorders as well as perceived stress during follow-up taking into account psychological adjustment (response shift) ; b) The coping strategies (process of managing stressful circumstances) and post-traumatic growth (positive psychological change experienced as a result of the struggle with highly challenging life circumstances) ; c) The 2-year post transplantation graft survival and patient outcomes: evolution of the Graft Filtration Rate, the proteinuria level ; d) The Kidney Transplant Failure Score (KTFS, patent N°0959043) at one year post transplantation ; e) The post-transplantation time to return to work and patients compliance to treatment.
Study Type
OBSERVATIONAL
Enrollment
390
Patient-Reported Outcomes completion every six months prior to surgery, at hospital discharge, and at 3, 6,12, 24, 36, 48, 72 months
CHU LYON - Hôpitla E. Herriot - Médecine de transplantation et immunoclinique
Lyon, France
CHU MARSEILLE - Hôpital de la Conception - Santé Publique
Marseille, France
CHU NANTES - Hôtel Dieu-Jean Monnet - ITUN
Nantes, France
CHU NICE - Service de Néphrologie
Nice, France
Change in quality of life
The change in quality of life, taking into account psychological adjustment of the patient (response shift). This criterion will be measured by a specifically developed questionnaire : ReTransQol
Time frame: through study completion, an average of 5 years
Generic quality of life
Generic QoL will be assessed with the SF36 every 6 months prior to surgery, at hospital discharge and at 3, 6,12, 24, 36, 48, 72 months and compared between PPT versus PDT.
Time frame: through study completion, an average of 5 years
Anxiety and depressive disorders
Anxiety and depressive disorders will be assessed every six months prior to surgery, at hospital discharge, and at 3, 6,12, 24, 36, 48, 72 months and compared between PPT versus PDT using the questionnaire HAD (Hospital Anxiety and Depression scale)
Time frame: through study completion, an average of 5 years
Subjective well-being
Subjective well-being will be assessed every six months prior to surgery, at hospital discharge and at 3, 6,12, 24, 36, 48, 72 months and compared between PPT versus PDT using the satisfaction with life scale (SWLS)
Time frame: through study completion, an average of 5 years
Perceived stress
The perceived stress will be assessed every six months prior to surgery, at hospital discharge, and at 3, 6,12, 24, 36, 48, 72 months and compared between PPT versus PDT with the Perceived Stress Scale
Time frame: through study completion, an average of 5 years
Coping strategies
The coping strategies will be assessed at 3, 6,12, 24, 36, 48, 72 months post transplantation and compared between PPT versus PDT with the Brief Cope
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
CHU TOULOUSE - Hôpitalt Rangueil - Service de Néphrologie
Toulouse, France
Time frame: through study completion, an average of 5 years
Posttraumatic growth
The posttraumatic growth will be assessed at 3, 6,12, 24, 36, 48, 72 months post transplantation and compared between PPT versus PDT with the Posttraumatic Growth Inventory (PTGI)
Time frame: through study completion, an average of 5 years
Evolution of the Graft Filtration Rate
The evolution of the Graft Filtration Rate (GFR) will be compared between PPT versus PDT. This clinical parameter will be collected at hospital discharge, and 3, 6,12, 24, 36, 48, 72 months post-transplantation. Renal function will be estimated using the 4-variables MDRD formula
Time frame: through study completion, an average of 5 years
Evolution of daily proteinuria level
The evolution of the daily proteinuria level will be compared between PPT versus PDT. This clinical parameter will be collected at hospital discharge, and 3, 6,12, 24, 36, 48, 72 months post-transplantation. Conventionally, proteinuria is diagnosed by a simple dipstick test
Time frame: through study completion, an average of 5 years
KTFS (Kidney Transplant Failure Score )
The Kidney Transplant Failure Score (KTFS) at one year post transplantation will be compared between PPT versus PDT.
Time frame: 12 month
Post-transplantation time to return to work
Time frame: 24 month
Compliance of patients
Compliance of patients will be assessed every six months prior to surgery, at hospital discharge, and at 3, 6,12, 24, 36, 48, 72 months and compared between PPT versus PDT with the Girerd questionnaire
Time frame: through study completion, an average of 5 years