The protocol is a large registry to describe acute, sub-acute and extended duration of anticoagulation management, clinical and economic duration of anticoagulation management, clinical and economic outcomes in patients with treated acute VTE (DVT and PE) in the real-world setting. Main objectives are to clarify the: * treatment related details for acute VTE (either conventional anticoagulation therapy, treatment with a direct oral anti-coagulant or other modalities of treatment) * Rate of early and late symptomatic VTE recurrence * Rate and nature of complications of VTE including post thrombotic syndrome and chronic thromboembolic pulmonary hypertension * Rate of bleeding complications * Rate of all-cause mortality at six months
Other objectives are to clarify the additional outcomes of: * Stroke (Measured by number of incidences) * Transient Ischemic Attack (TIA) (Measured by number on incidences) * ST Elevated Myocardial Infarction (STEMI) (Measured by number of incidences) * Non-ST Elevated Myocardial Infraction (NSTEMI) (Measured by number of incidences) * Unstable Angina (Measured by number of incidences) * Quality of life and patient reported outcomes and costs associated with the management of VTE.
Study Type
OBSERVATIONAL
Enrollment
10,679
Dr Terence Hart
Muscle Shoals, Alabama, United States
Rate of recurrent symptomatic VTE (DVT and fatal or non-fatal PE)
Rate of recurrent symptomatic VTE (DVT and fatal or non-fatal PE)
Time frame: 36 months
Bleeding events
Frequency, location, severity (classified as major or non-major)
Time frame: 36 months
Hospitalization
Measured by number of occurrences.
Time frame: 36 months
Post Thrombotic Syndrome
Measured by number of occurrences and severity.
Time frame: 36 months
Chronic thromboembolic pulmonary hypertension
Measured by number of occurrences and severity.
Time frame: 36 months
IVC filter placement
Measured by number of occurrences.
Time frame: 36 months
Other urgent interventions for VTE
Measured by number of occurrences.
Time frame: 36 months
Anticoagulation therapy persistence
Estimation of Anticoagulation therapy will be compared to actual total time Anticoagulation therapy was used by patients.
Time frame: 36 months
All cause of mortality
Causes of death: PE, stroke, cardiac, cancer-related, other...
Time frame: 36 months
International Normalized Ratio (INR) Values in Patients treated with Vitamin K Antagonists
Will be assessed by frequency of INR monitoring, and number of INR readings taken before patient achieved optimum range.
Time frame: 36 months
Stroke
Ischemic stroke, hemorrhagic stroke
Time frame: 36 months
Trans Ischemic Attack (TIA)
Measured by number of occurrences.
Time frame: 36 months
Myocardial Infarction
Measured by number of occurrences of both ST-Elevated Myocardial Infarction and Non-ST Elevated Myocardial Infarction (STEMI/NSTEMI).
Time frame: 36 months
Unstable angina
Measured by number of occurrences.
Time frame: 36 months
Quality of life and patient treatment satisfaction over a three year period
Measured by Questionnaire.
Time frame: 36 months
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