This study is a prospective randomized trial to evaluate and compare the quantitative and qualitative characteristics of neointimal formation between high and low efficacy statin treatment after drug eluting stent (DES) implantation, in patients with homogeneous or heterogeneous neointimal pattern accessed by Optical Coherence Tomography (OCT). The investigators postulate that high efficacy statin could have superior effect on modification of neointimal pattern, compared with lower efficacy statin. Our main hypothesis is that Atorvastatin 40mg, high efficacy statin might have superior effect on modification of neointimal pattern evaluated by serially followed OCT, compared with pravastatin 20mg in patients with DES implantation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
homogenous neointimal pattern at baseline OCT and randomized to atorvastatin 40 mg group
Intervention description : homogenous neointimal pattern at baseline OCT and randomized to pravastatin 20 mg group
Severance Hospital
Seoul, South Korea
Change of neointimal patterns assessed by 1-year followed OCT
Qualitative neointimal pattern measured by OCT such as restenotic tissue structure
Time frame: at 1 year
stent coverage and neointimal thickness
Change of stent coverage and neointimal thickness assessed by 1-year followed OCT
Time frame: at 1 year
Major adverse cardiac events
MACE (Major adverse cardiac events) including cardiovascular/unexpected mortality, non-fatal myocardial infarction, target lesion revascularization
Time frame: at 1 year
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