Fibrinogen in Haemorrhage of Delivery

Inclusion Criteria: * Signed and dated informed consent form * Vaginal delivery * PPH requiring IV administration of prostaglandins * At least one available result of Hb level during the third trimester of pregnancy * 18-year-old female patients and older * Covered by healthcare insurance in accordance with local requirements Exclusion Criteria: * Caesarean section * Haemostatic intervention (as ligation, embolization or hysterectomy) already decided at the time of inclusion * Known placenta praevia or accreta * Hb level \< 10g/dl during the third trimester of pregnancy * History of venous or arterial thromboembolic event * Known inherited bleeding or thrombotic disorders * Treatment with low-molecular-weight heparin (LMWH) within 24 hours prior to the inclusion * Treatment with acetylsalicylic acid within 5 days prior to the inclusion * Treatment with vitamin K antagonists within 7 days prior to the inclusion * Administration of fibrinogen concentrate within 48 hours prior to the inclusion * Administration of FFP, platelets units or prohaemostatic drugs, tranexamic acid and rFVIIa or prothrombin complex concentrates (PCC) within 48 hours prior to the inclusion * Administration of RBCs within 3 months prior to the inclusion * Participation in another interventional clinical study within 30 days prior to the inclusion * Previous inclusion/enrolment in the present clinical study * Known history of hypersensitivity or other severe reaction to any component of Clottafact® or placebo * Minors, majors under guardianship, persons staying in health or social institutes and people deprived of their freedom * Known drug or alcohol abuse * Patients whose use of concomitant medication may interfere with the interpretation of data * Any other current significant medical condition that might interfere with treatment evaluation according to the investigator's judgement * Patients who are unlikely to survive through the treatment period and evaluation * Patients transferred from another service