The purpose of this study is to determine whether endurance exercise of either high or moderate intensity can reverse structural and functional changes of the heart in patients with diastolic heart failure, and to investigate which type of exercise is best in terms of aerobe capacity and quality of life. The investigators expect that high intensity endurance exercise is superior to moderate intensity endurance exercise.
This study is a prospective randomized controlled intervention study comparing two active arms. Eligible patients are being sampled consecutively by cardiologists, and randomized to either high or moderate intensity endurance exercise. Endpoints are measured at baseline, 4 weeks and 7 months. The intervention is considered safe, and the study has been approved by the Regional Ethics Committee (REK-midt). This project has been financially supported by the Norwegian ExtraFoundation for Health and Rehabilitation through EXTRA funds.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
LHL Klinikkene
Røros, Norway
Change in aerobic capacity measured as oxygen consumption
Cardiopulmonary exercise test
Time frame: Baseline and 7 months
Feasibility, measured as attrition rate and compliance with exercise
Time frame: Baseline to 7 months
Blood-risk profile, measured as changes in cholesterol, hemoglobin, N terminal-proBNP
Time frame: Baseline to 7 months
Cardiac function measured as volume, size, efficacy
Ultrasound
Time frame: Baseline to 7 months
Arterial function measured as blood-vessel elasticity
Ultrasound
Time frame: Baseline to 7 months
Quality of life
Self-reported questionnaires
Time frame: Baseline to 7 months
Changes in everyday activity level
Self-reported questionnaire, diary, activity monitoring device
Time frame: Baseline to 7 months
Change in diastolic filling pressure measured as E/é
Ultrasound
Time frame: Baseline to 7 months
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