Evaluation of Non-cultured Epidermal Cellular Grafting vs Hyaluronic Acid for Repigmenting Vitiligo and Piebaldism

Inclusion Criteria: * Men and women aged over 18 years old with a diagnosis of non-scaring leukoderma that has been stable over the last 2 years (non-segmental, segmental vitiligo and piebaldism) * For non-segmental vitiligo: symmetrical vitiligo lesions, or parts of a lesion. A part of at least 1 cm2 (1 x 1 cm), but preferable 4 cm2 (2x2 cm) and preferably in the center of each lesions (left/right) should be treated. The minimum distance between the normal pigmented skin and the test area should preferably be at least 0.5 cm. * For segmental vitiligo lesion and piebaldism: all lesions possible if two parts of at least 1 cm2 (1 x 1 cm), but preferably 4 cm2 (2 x 2 cm) in the lesion can be treated. The minimum distance between the 2 areas should be 2 cm and between test areas and to the normal pigmented skin preferably at least 0.5 cm. * Medical treatments of vitiligo failed (in case of vitiligo: at least cream treatment for 6 months). * Absence of infected lesion * Negative serology (HIV-hepatitis B and C- Syphilis) * Without treatment one month for cream and 3 months for phototherapy Exclusion Criteria: * Hypersensibility to local anaesthetics or one of the components of the device (trypsin, hyaluronic acid) * Indication against biopsies * Patient with a history of melanoma * Positive serology (ongoing serious systemic disease, herpes, HIV, hepatitis B and C-Syphilis) * Positive pregnancy test * History of keloidal scars and presence of Koebner's phenomenon (type 1 and type 2b) * Infected lesion * Test areas not on fingers and toes vitiligo areas in case of non-segmental vitiligo * Test areas not on facial non segmental vitiligo * Pregnant women, or lactating * Age \<18years * Major deprived of their freedom by administrative or legal decision, or being the subject of a legal protection measure, or out of state to express their consent