DAA-based Therapy for Recently Acquired Hepatitis C II (DAA = Directly Acting Antiviral)

Inclusion Criteria: * Provision of written informed consent * Male and female patients aged 18 years and above * Willing to use two effective methods of contraception during the treatment period and 24 weeks post. * HBsAg negative * Detectable HCV RNA at screening (\>10,000 IU/ml), and in the opinion of the investigator is unlikely to demonstrate spontaneous viral clearance * Compensated liver disease (Child-Pugh A) * Negative pregnancy test at screening and 24 hours prior to first dose of study drugs * Medically stable on the basis of physical examination, medical history and vital signs * Adequate English to provide reliable responses to the study questionnaires * Recent hepatitis C infection, as defined by: A) i) First anti-HCV Ab or HCV RNA positive within the previous 6 months and ii) Documented anti-HCV Ab negative within the 24 months prior to anti-HCV antibody positive result, OR B) i) First anti-HCV Ab or HCV RNA positive within the previous 6 months and ii) acute clinical hepatitis (jaundice or ALT\> 10 X ULN) within the previous 12 months prior to first positive HCV antibody or HCV RNA, with no other cause of acute hepatitis identifiable If co-infection with HIV is documented, the subject must meet the following criteria: * Antiretroviral (ARV) untreated for \>8 weeks preceding screening visit with CD4 T cell count \>500 cells/mm3 OR * On a stable ARV regimen for \>8 weeks prior to screening visit, with CD4 T cell count \>200 cells/mm3 and an undetectable plasma HIV RNA level. Exclusion Criteria: * Standard exclusions to RBV therapy * Pregnancy/lactation or male subjects whose female partners are pregnant * Subject has a history of decompensated liver disease: history of ascites, hepatic encephalopathy, or bleeding oesophageal varices, and/or any of the following screening laboratory results: a.INR of ≥1.5; Serum albumin \<3.3 g/dL; Serum total bilirubin \>1.8 times upper limit of normal, unless isolated in subjects with Gilbert's syndrome.