Frailty: Prevalence and Response to Left Ventricular Assist Device Therapy in Older Heart Failure Patients

Thomas Jefferson University20 enrolled

Overview

This is an observational study evaluating changes in frailty and associated impairments in older heart failure patients receiving left ventricular assist device therapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Systolic Heart Failure

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 60 years old or older * Scheduled to undergo left ventricular assist device implantation at Thomas Jefferson University Exclusion Criteria: * Unable or unwilling to provide informed consent * Unable to complete baseline frailty assessment

Locations (1)

Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

Change in frailty following left ventricular assist device implantation

Frailty will be assess based on the domains initially described by Fried and colleagues: weakness, low physical activity, unintentional weight loss, slowness and exhaustion. Additional frailty measures include the Short Physical Performance Battery (SPPB), as well as gait speed and hand grip strength as single item measures.

Time frame: Baseline (prior to surgery); 10 days, 1 month, 3 months, and 6 months post-operatively

Secondary Outcomes

Skeletal muscle size as measured by ultrasonography

Time frame: Baseline (prior to surgery); 10 days and 3 months postoperatively

Data from ClinicalTrials.gov

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