The investigators want to investigate if patients with Oculopharyngeal Muscular Dystrophy can improve fitness by home-training on a cycle ergometer 30 minute, 3 times a week for 10 weeks. Participants will be evaluated on maximal oxygen consumption and maximal workload measured by an incremental test at baseline and at the end of the exercise period.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
8
Ten weeks of home-training on a cycle ergometer 3 times a week for 30 minutes.
Neuromuscular Research Unit
Copenhagen, Denmark
RECRUITINGEfficacy based on VO2max
Difference in VO2max measured before and after intervention
Time frame: 10 weeks
SF-36 Questionaire
Changes in self-rated health from baseline to end of intervention
Time frame: 10 weeks
6 minute walk test
Changes in walking distance from baseline to end of intervention
Time frame: 10 weeks
Intensity in maximal load (Watt)
Changes in maximal load (watt) in the VO2max-test from baseline to end of intervention.
Time frame: 10 weeks
Level of plasma creatine kinase
Marker for exercise-induced muscle damage. Taken week 0,3 and 10.
Time frame: 10 weeks
Level of plasma myoglobin
Marker for excercise-induced muscle damage, taken week 0, 3 and 10.
Time frame: 10 weeks
6 minute walk test
Changes in walking distance in the test from baseline to end of intervention.
Time frame: 10 weeks
A five-time-repetition-sit-to-stand-test
Changes in time of five repetitions from baseline to end of intervention
Time frame: 10 weeks
A 14-step-stair-test
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Changes in time completing the test from baseline to end of intervention
Time frame: 10 weeks
Dynamometry
Changes in external force production from baseline to end of intervention. Dynamometry are measured on hip flexion, dorsal foot flexion, plantar foot flexion, knee flexion, knee extension, and elbow flexion.
Time frame: 10 weeks