Technology That Permits Focal Dose of Antibiotics to be Delivered to Lower Limb(s) of Diabetic Patients

Inclusion Criteria: * M or F subjects 18 - 90 years old * Subject has pre-existing diabetes diagnosis * Subject has significant infection below the ankle of soft tissue and may include bone, and IV antibiotics are needed in order to salve limb or life * Consequence of infected wound would require Std of Care share debridement * Subject willing and able to provide written informed consent * Subject willing and able to comply with requirements of study protocol including pre-defined follow-up evaluations * PROCEDURAL INCLUSION CRITERIA: successful cannulation of the femoral artery and vein and placement of the venous support device Exclusion Criteria: * Allergy to contrast media * Known bleeding disorder including thrombocytopenia * Recent AMI or elevated Troponin levels within last 30 days * Penicillin sensitivity; Timentin sensitivity * Female subjects known to be or suspected to be pregnant or lactating * Subject unable to comply with instructions; especially to remain supine for duration of recirculation procedure * Subjects who have participated in any other clinical trial or taken investigational drug within 30 days of study enrollment * The PI determines the subject is not an appropriate subject for the study * PROCEDURAL EXCLUSION CRITERIA: Subjects anatomy interferes with or is expected to prohibit successful cannulation of the femoral vessels or placement of the venous support device * Known severe proximal femoral artery vascular disease precluding placement of perfusion catheters