The main aim of the study is to investigate the effects of dietary ingredients (polyphenols and carotenoids) on vascular function during acute glucose load. Each subject will receive 4 weeks of intervention with test product or placebo product after a dietary restriction run-in period of 14 days. Subjects will be challenged with an oral glucose tolerance test (OGTT) immediately after the run-in phase and at the end of the intervention phase. During the OGTT, blood samples will be taken at regular intervals. The study will be conducted in subjects with impaired glucose tolerance.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
50
Placebo intervention
Aspect Clinical
Ledbury, United Kingdom
Interleukin-6 (IL-6) levels.
Time frame: At baseline (after 2 weeks run-in period) and after 4 weeks intervention
Pro-inflammatory and oxidative stress biomarkers
* Luminex HS cytokine, CVD, ADK and MMP panel * Endothelial derived factors * Systemic inflammatory cytokines: hsTNFα * Systemic inflammatory cytokines: hsCRP * Endothelial cell function markers * Oxidative stress parameters
Time frame: At baseline (after 2 weeks run-in period) and after 4 weeks intervention
Cell stress-defence responses
* Direct \& indirect markers of cell defence activation * Inflammatory and oxidative stress markers * Established and exploratory cardiovascular health markers
Time frame: At baseline (after 2 weeks run-in period) and after 4 weeks intervention
Clinical chemistry parameters
* Glucose \& Insulin * Total cholesterol, LDL, HDL, triglycerides, uric acid, Glycated Serum Proteins \& HbA1C.
Time frame: At baseline (after run-in period of 2 weeks) and after 4 weeks intervention
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