To investigate relative bioavailability of crushed tablets suspended in apple sauce or water
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
NONE
Enrollment
48
Single dose of a whole 2.5 mg riociguat tablet
Unnamed facility
Mönchengladbach, North Rhine-Westphalia, Germany
Pharmacokinetics of riociguat in plasma by Area under the plasma concentration time curve (AUC)
Time frame: Multiple time points up to day 3
Pharmacokinetics of riociguat in plasma by maximal concentration (Cmax)
Time frame: Multiple time ponits up to day 3
Number of participants with adverse events as a measure of safety and tolerability
Time frame: Up to 12 weeks
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