Microgynon Riociguat Drug Interaction Study in Healthy Postmenopausal Women

Inclusion Criteria: * Healthy female subject * Non-smokers of at least 3 month before screening * Age: 52 to 65 years (inclusive) at the first screening examination * Ethnicity: white * Body mass index (BMI)\>=20 and \<=32 kg/m2 * Postmenopausal state, defined as * Medical history, if applicable (natural menopause at least 12 months before the first study drug administration and hormone analyses in serum * Age\<60 years: follicle-stimulating hormone (FSH) \>40 IU/L in plasma * Age \<60 years: estradiol (E2) \<20 ng/L (\<73 pmol/L) in plasma Exclusion Criteria: * History of coronary artery disease, Symptomatic postural hypotension, History of bronchial asthma, known hypersensitivity to the study, relevant diseases within 4 weeks before study drug administration, * Presence or a history of venous or arterial thrombotic / thromboembolic events or cerebrovascular accident, a high risk for venous or arterial thrombosis, * Use of systemic or topical medicines or substances which oppose the study objectives, smoking, use of sex hormones in any forms * Clinically relevant findings in the ECG, systolic blood pressure below 110 or above 145 mmHg, heart rate below 50 or above 95 beats per minute * Clinically relevant findings in the gynecological examination, * Participation in another clinical study