In Vitro Functional Modulation of Monocyte-derived Dendritic Cells of Patients With Cancer by Peptides

Inclusion Criteria: 1. Signature of the Informed Consent Form before the performing of any procedures related to the study; 2. Age ≥18 years; 3. Histologically confirmed metastatic malignant neoplasia; 4. Results of laboratorial exams in the first 6 weeks before the blood sample collection within the following values: * White blood cells ≥ 3.000/μL; * Platelet count ≥ 100,000/mm³; * Hemoglobin \> 10g/dL; * Serum aspartate aminotransaminase (AST), alanine aminotransferase (ALT) and alkaline phosphatase \< 2.5 x upper limit of normal (ULN); * Serum creatinine \< 1.5 x upper limit of normal (ULN); 5. Karnofsky performance status ≥ 70%. Exclusion Criteria: 1. Presence of autoimmune disorders or conditions that require systemic treatment with immunosuppressant medications or systemic corticosteroids; 2. Received any systemic chemotherapy or radiotherapy within 15 days prior to the blood sample collection; 3. Received any immunotherapy within 4 weeks prior to the blood sample collection; 4. Known history of positive serology for HIV (human immunodeficiency virus).