Functional magnetic resonance imaging in women with chronic pelvic pain using arterial spin labelling, functional connectivity, diffusion tensor imaging and magnetic resonance spectroscopy.
Multimodal magnetic resonance neuroimaging will be utilised. Arterial spin labelling is tightly coupled with cerebral metabolism and can be used as a marker of neural activity. Resting state magnetic resonance imaging which measures synchronous activity across the brain, allows detection of functional connectivity of intrinsic brain network. Diffusion tensor imaging detects the anisotropic water diffusion in axonal fibres can provide information on connectivity and fibre tracts. Magnetic resonance spectroscopy would enable the levels of neurotransmitter to be elucidated.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
3 Tesla magnetic resonance imaging
KK Women's and Children's Hospital
Singapore, Singapore
Number of participants with increase in insula anterior cingulate cortex signal on magnetic resonance imaging
Magnetic resonance imaging using arterial spin labelling, functional connectivity, diffusion tensor imaging, magnetic resonance imaging
Time frame: 1 hour
Number of subjects in psychological testing with increased anxiety, depression and pain catastrophizing scores
Anxiety, depression and pain catastrophizing scales used for psychological testing
Time frame: 1 hour
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