To examine pancreatic islet function and incretin function during intravenous and oral stimulation \>2 years after gastric bypass surgery in patients with normal glucose tolerance. We hypothesize that islet cell and incretin function is enhanced in response to oral, but not intravenous, stimulation - i.e. incretin released from the gut in response to oral stimulation play a key role for the enhanced islet function after gastric bypass surgery.
Study Type
OBSERVATIONAL
Enrollment
7
Hvidovre University Hospital
Hvidovre, Danmark, Denmark
Change in islet cell function from baseline (preoperatively)
Change in insulin and glucagon secretion during oral and intravenous stimulation after gastric bypass
Time frame: >24 months
Change in glucose tolerance during oral glucose tolerance test
Fasting, peak and nadir glucose during oral glucose tolerance test
Time frame: >24 months
Arterio-venous glucose difference during oral glucose tolerance test after gastric bypass
Differences in arterial and venous plasma glucose during oral glucose stimulation
Time frame: >24 months
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