Assessments of Dietary Restrictions in Young and Elderly Obese Men : Metabolism Obesity Nutrition Age

N/ACompletedNCT02161926

University Hospital, Toulouse71 enrolled

Overview

The prevalence of obesity is growing in elderly with heavy consequences in term of medical complications and mortality, so that this is nowadays an important public health issue. The major therapeutic solution is dietary restrictions, but and the advantages and the metabolic consequences are not well known in elderly. The MONA study main aim is to assess the metabolic changes in this population, after dietary restrictions, compared to young people.

Primary endpoint : Study the metabolic adaptations of the subcutaneous adipose tissue after a diet in elderly obese men compared to young obese men. Secondary endpoints : Study the metabolic adaptations of skeletal muscle, the genetic adaptations of subcutaneous adipose tissue and skeletal muscle, the inflammatory and fibrosis modifications of subcutaneous adipose tissue, the insulinosensibility modifications, the modifications on the physical composition, modifications of the energy expenditure in resting state and the oxidation of the substrata, study the lipoproteins metabolism and identify new biomarkers. All those endpoints are studied comparing elderly obese subjects versus young obese subjects.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Obesity

Interventions

dietary restrictionsOTHER

Dietary restrictions during 8 weeks

Eligibility

Sex: MALEMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 30 \< years old \< 40 OR 60 \< years old \< 70 * obesity : 30 \< BMI \< 40 * stable blood pressure (diastolic \<90mmHg, systolic \< 140mmHg) * glycemia \< 1,26g/L, LDL cholest \<1,9-1,6g/L, Triglycerides \<2,5g/L * risk factors concerning high blood pressure, diabetes and dyslipidemia under control Exclusion Criteria: * Insulin dependent diabetes, non-insulin dependent diabetes * high blood pressure * dyslipidemia * history of cardiovascular diseases or bariatric surgery * undernutrition * HbA1C \>7% * non authorized treatments : Glucagon-like peptide-1 agonists, * incapacity to do physical activity

Locations (1)

University Hospital Toulouse

Toulouse, France

Outcomes

Primary Outcomes

Lipolysis at resting and during physical activity test

Determine lipolysis at resting and during physical activity test by microdialysis, before dietary restrictions and after dietary restrictions (20% dietary restrictions)