CD34+ Cell Enriched and T Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Mismatched Related Donors or Borderline Organ Function

Inclusion Criteria: * Participant age is 0 (newborn) to 35 years-old. * Participant has a disorder affecting the hematopoietic system that are inherited, acquired, or a result from the myeloablative treatment that can benefit from alternative stem cell transplantation according to standard practice guidelines for including patients for transplant. * Participant's medical screening clears s/he for allogeneic transplantation as per current institutional SOP based on standards of foundation for accreditation of cellular therapy and stem cell transplantation (FACT); * Participant must lack a healthy, HLA-identical related or unrelated donor unless s/he has a borderline organ function that will preclude the recipient from receiving a curative therapy due to the need of post-HSCT immunosuppressive therapy. * Participant must have a matched or mismatched-related donor who is: * Able to receive granulocyte colony-stimulating factor (G-CSF) and undergo apheresis either through placement of catheters in antecubital veins or a temporary central venous catheter OR agrees on a bone marrow harvest; * Healthy as per donor selection screening (following current SOP based on standards of foundation for accreditation of cellular therapy and stem cell transplantation - FACT); * Willing to participate and sign consent. * Participant or Legal Authorized Representative is able to sign informed consent (and signed assent, if applicable) for transplant. Exclusion Criteria: * Participant does not qualify for an allogeneic transplant due to medical screening, underlying disease, or lack of alternative donors. * Any condition that compromises compliance with the procedures of this protocol, as judged by the principal investigator.