Salivary Cortisol Measurements by Mass Spectrometry

Stanford University50 enrolled

Overview

Cortisol is a hormone critical for survival in times of stress. Currently most measurements are done with blood samples. The hypothesis of this study is cortisol measured from saliva using mass spectrometry can be used to replace measurements by blood.

Cortisol levels change depending on the time of day. Salivary samples were collected from health controls at bedtime, midnight and first morning waking on two consecutive nights and salivary cortisol levels were measured using mass spectrometry. In a patients with possible endocrine disorders who were going through an adrenocortiotropin stimulation test for adrenal insufficiency, salivary cortisol was measured prior to giving cosyntropin and 30-40 minutes after cosyntropin.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Endocrine Disorders

Interventions

Non intervention studyOTHER

Eligibility

Sex: ALLMin age: 3 YearsMax age: 17 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Normal subjects * Subjects with possible endocrine disorder Exclusion Criteria: * Tracheostomy or ventilator dependent * Gastrotomy tubed dependent or unable to eat/drink by mouth

Locations (1)

Lucile Packard Children's Hospital and Stanford Clinics

Stanford, California, United States

Outcomes

Primary Outcomes

Salivary Cortisol

Time frame: All collections are done within 48 hours

Data from ClinicalTrials.gov

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