This is a technical development study with the goal to develop 3D techniques for atherosclerosis plaque characterization. We hypothesize that 3D MRI is superior to 2D MRI in characterizing major plaque constituents that contribute to severe clinical events such as myocardial infarction or stroke. The major advantages of the 3D techniques to be developed will include high spatial resolution, reduced scan times, and optimized image contrast. The use of contrast injection is not needed with the new techniques, which is greatly beneficial for patients with advanced chronic kidney disease.This is not a funded clinical trial.
All participants will undergo the conventional MRI protocol and the new imaging protocol using our developed techniques. They may have either non-contrast scans or contrast-enhanced scans or both depending on the stage of development. The comparison results between the two protocols will be used to evaluate the performance of the new techniques and help optimization of specific technical aspects.
Study Type
OBSERVATIONAL
Enrollment
134
Bilateral carotid plaque imaging at 3.0T. Conventional MRI scans with T1-, T2-weightings and scans using the developed techniques. MR contrast may be used in conventional protocol when it is needed to evaluate the performance of the developed techniques
Cedars-Sinai Medical Center
Los Angeles, California, United States
Image quality score
Images collected from both investigational MRI pulse sequences and conventional protocol will be reviewed and scored by readers and compared.
Time frame: Within one year of scans
Adverse plaque characteristics detection
In patient study, the analysis of adverse plaque characteristics will be performed and compared between the conventional protocol and developed protocol.
Time frame: Within one year of scans
Image contrast-to-noise ratio
Contrast-to-noise ratio will be measured on the images collected with the conventional protocol and developed protocol and compared.
Time frame: Within one year of scans
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