The Use of Tranexamic Acid (TXA) Intravenously, to Reduce Blood Loss in Proximal Femur Surgery

Phase 4WithdrawnNCT02164565

HaEmek Medical Center, Israel

Overview

The use of Tranexamic Acid (TXA) intravenously, to Reduce Blood Loss in proximal femur surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Conditions

Femur Surgery

Interventions

Tranexamic Acid (TXA) treatmentDRUG

Tranexamic Acid (TXA) treatment

control grup: without Tranexamic Acid (TXA) treatment.DRUG

control grup: without Tranexamic Acid (TXA) treatment.

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients over 60, who came to the orthopedic department for proximal femur fracture surgery * Sound judgment Exclusion Criteria: * Known hypersensitivity to Tranexamic Acid or component solution provided * Subarachnoid hemorrhage * Acquired color blindness * Myocardial infarction in 12 months before admission * Unstable angina * Known clotting disorders (Thromboembolic disease in the past, elongated PT and PTT, hypercoagulability), * Kidney or liver failure * Another situation prostate resection , pathologic fractures according to anamnesis or by imaging * Oncology patients * Patients on anticoagulation * Patients undergoing vascular intervention ( coronary or peripheral ), which was inserted Supporter requires a Dual antiplatelet therapy

Locations (1)

Orthopedic Department, HaEmek Medical Center

Afula, Israel

Outcomes

Primary Outcomes

Evaluation of blood loss in ml.

Hbloss=BV X (Hbi - Hbe) X 0.001 + Hbt Hbi - hemoglobin level before the surgery ) gram X liter-1(. Hbe - hemoglobin level 3 days after the surgery ( gram X liter-1). Hbt - The amount of hemoglobin that was given in the blood transfusion (gram). Hbloss - Change of hemoglobin loss. After calculating the amount of loss of hemoglobin, the volume of blood lost can be found: Blood loss = 1000 X Hbloss/ Hbi Evaluation of blood loss will be through: 1\. Comparing hemoglobin level before and after surgery and calculation of quantitative Change of hemoglobin loss. 2 .Registration evaluating blood loss at the end of surgery 3. Collecting and recording blood drain. 4. Tracking Blood Transfusion. Of course we collect the data: assessment of bleeding in the analysis, the number of blood units given, the amount of blood collected drain

Time frame: up to 13 months

Data from ClinicalTrials.gov

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