Bilateral Deficit Phenomenon in Patients With Haemophilic Arthropathy

Universidad Católica San Antonio de Murcia17 enrolled

Overview

Trial to assess the bilateral deficit phenomenon during dynamic plantar flexion task in patients with haemophilic arthropathy Describe the differences in terms of the physical variables (muscular strength, range of motion and proprioception) in patients with hemophilia who have conducted a home treatment with a digital tool. Bookmark the relationship between clinical history of joint bleeds and clinical manifestations in standing and walking.

* Assess the bilateral deficit phenomenon during dynamic plantar flexion task in patients with haemophilic arthropathy. * Indicate the independent variables that influence the development of strength and contractile activity, with or without previous joint bleeds in haemophilia patients with minors. * Observe the descriptive variables people influence the standing, the incorporation from sitting and jumping.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hemophilia

Interventions

Patients with haemophiliaOTHER

Assessment of bilateral deficit phenomenon during dynamic plantar flexion task with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with hemophilia A and B. * With or without joint involvement clinically diagnosed, and with or without a previous history of hemarthrosis joint load legs. * In prophylactic regimen with FVIII / FIX concentrates . * Residents in the Autonomous Community of the Region of Murcia. Exclusion Criteria: * Patients without walking ability. * Patients diagnosed with other congenital coagulopathy (von Willebrand disease, etc..). * Patients with neurological or cognitive impairments that prevent understanding the questionnaires and physical tests. * Patients whose parents or guardians have not signed the informed consent document.

Locations (1)

Universidad Católica San Antonio, Murcia

Murcia, Murcia, Spain

Outcomes

Primary Outcomes

Assessment of Bilateral Index of Maximal Peak Force

Assessment of bilateral index of maximal peak force with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA).

Time frame: Screening visit

Assessment of Bilateral Index of Rate of Development During the Preparation Phase

Assessment of Bilateral index of rate of development during the preparation phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)

Time frame: Screening visit

Assessment of Bilateral Index of Rate of Development During the Acceleration Phase

Assessment of bilateral index of rate of development during the acceleration phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)

Time frame: Screening visit

Assessment of Maximal Peak Force

Assessment of maximal peak force with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)

Time frame: Screening visit

Assessment of Rate of Development During the Preparation Phase

Assessment of rate of development during the preparation phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)

Time frame: Screening visit

Change of Joint Condition Based on Clinical Assessment

Spanish version of the Haemophilia Joint Health Score 2.1 (HJHS). Additive scale that assesses from 0 to 24 points joint status of patients with haemophilia (0: no joint damage; 24: maximum joint damage). The variables studied in this scale are: Swelling (range 0-3); Duration of swelling (range 0-1); Muscle atrophy (range 0-2); Crepitant in motion (range 0-2); Loss of Flexion (range 0-3); Loss of extension (range 0-3); Joint pain (range 0-2): Strength (range 0-4); Gait (range 0-4)

Data from ClinicalTrials.gov

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Secondary Outcomes

Weight of the Patients With Haemophilia

The weight were collected using a TANITA equipment (TBF-300WA model, Tanita Corporation of America, Inc., Illinois, USA)

Time frame: Screening visit

Diagnosis, Severity of Hemophilia, Treatment (Prophylactic or on Demand)

Patients fill out a registration key clinical data (type, severity of hemophilia, hemarthrosis in the previous month and current drug therapy).

Time frame: Screening visit

Joint Bleeding Before the Assessment

Time frame: Screening visit

Height of the Patients With Haemophilia

The height of patients was calculated using a TANITA equipment (TBF-300WA model, Tanita Corporation of America, Inc., Illinois, USA).

Time frame: Screening visit

Body Mass Index of Patients With Haemophilia

The body mass index of patients was calculated using a TANITA equipment (TBF-300WA model, Tanita Corporation of America, Inc., Illinois, USA).

Time frame: Screening visit

Age of Patients With Haemophilia

Time frame: Screening visit