Hibiscus sabdariffa calyces (HSC) extract is consumed in different parts of the world as a cold or hot drink and is available in the United Kingdom (UK) markets in different forms including tea bags. There is preliminary data that support the hypothesis that HSC extract consumption has beneficial effect on blood vessel health and blood pressure reduction. Hypertension, vascular dysfunction, inflammation and lipid abnormalities are all key modifiable risk factors of cardiovascular diseases (CVD), the leading causes of death throughout the world. In the PHYTOVAS (PHYTOchemicals and VAScular Function) study the effect of the acute consumption a potentially bioactive food extracts: Hibiscus sabdariffa calyces (HSC) compared with a matched control (water) on blood pressure and blood vessels function will be investigated after a high - fat mixed meal. This is with a view to determining the impacts of the extract on postprandial (after meal) blood pressure and other CVD risk factors. Results from the PHYTOVAS study could lead to identification of more dietary approaches that will contribute to CVD risk prevention and management.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
25
Department of Food and Nutritional Sciences, University of Reading,
Reading, Berkshire, United Kingdom
Change in baseline and hourly blood pressure
Time frame: Baseline, hourly 4 times post baseline and then hourly for twelve hours at night
Change in Flow Mediated Vasodilation
Time frame: Baseline, 2 and 4 hours post treatment
Change in blood lipids profile
Time frame: Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment
Change in Inflammatory marker: C - reactive protein (CRP)
Time frame: Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment
Change in plasma nitric oxide level
Time frame: Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment
Change in serum total antioxidant capacity
Time frame: Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment
Changes in serum or plasma glucose and insulin levels
Time frame: Baseline and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours post treatment
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