Analyze and evaluate the skeletal muscle of patients affected with hemophilia in the Region of Murcia. * Describe the periarticular muscular deficit of the lower limbs, depending on the degree of injury: acute and chronic, or subacute. * Identify the range of motion of joints with higher prevalence of hemophilic arthropathy. * Detect the biomechanical changes of the lower limbs and their impact on gait in patients with hemophilia. * Assess the factors that influence the perception of illness and quality of life of patients with hemophilia.
Descriptive study of joint involvement in hemophilia patients with and without a history of hemarthrosis in lower limbs. Descriptive study of alterations in the strength of the periarticular muscles of lower limbs as a result of acute conditions or the development of chronic articular sequelae. Descriptive study of the biomechanical alterations in weight-bearing joints of lower limbs and their impact on gait in patients with hemophilia. Descriptive study of the relationship between skeletal muscle pathology in patients with hemophilia and their perceptions of it and their quality of life.
Study Type
OBSERVATIONAL
Enrollment
60
Universidad Católica San Antonio, Murcia
Murcia, Murcia, Spain
RECRUITINGAssess the range of motion
Assess the range of motion of elbow, knee and ankle (using a goniometric evaluation).
Time frame: Screening visit
Assess the muscular strength
Assess the muscular strength of arm, thigh and leg (through measurement of muscle balance).
Time frame: Screening visit
Assess the joint pain
Joint pain (VAS scale with the use of a pressure algometer).
Time frame: Screening visit
Assess the variables of strength
Assessment of variables of vertical strength, medio-lateral and anterior-posterior in jump and incorporation from the sitting position.
Time frame: Screening visit
Assess the peak force
Functional assessment of peak force, force production per unit time and subsequent stabilization in standing (in jump and in the passage from the sitting position to standing position, respectively, using a force platform).
Time frame: Screening visit
Assess the contractile activity
Assessment of miotendinous contractile activity in the patellar tendon and Achilles, in jump (CMJ-stiffness test).
Time frame: Screening visit
Assess the state joint
State joint (applying Hemophilia Joint Health Score questionnaire).
Time frame: Screening visit
Assess the list of activities
List of activities in hemophilia (completing the autocuestionario Hemophilia Activities List).
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Time frame: Screening visit
Assess the physical performance
Perception of physical performance (with the HEP-Test-Q questionnaire)
Time frame: Screening visit
Assess the health Profile
Health Profile (using the scale Nottingham health profile)
Time frame: Screening visit
Assess the quality of life
Quality of life (using the SF-36 and Haemo-QoL-36 questionnaire).
Time frame: Screening visit
Age, sex, weight of the patients with hemophilia
Time frame: Screening visit
Diagnosis, severity of hemophilia, type of treatment (prophylactic or on-demand) and inhibitors
Time frame: Screening visit
Frequency of joint bleeds in the previous month and bleeding during the assessment
Time frame: Screening visit