The overall aims for this study are to determine whether UVB excimer laser treatment of psoriasis affects serum inflammatory markers, and to assess hyperpigmentation and erythema with excimer laser treatment. The investigators hypothesize that treatment of psoriasis with UVB delivered via 308 nm excimer laser will decrease the levels of serum inflammatory markers. The investigators hypothesize that treatment will decrease plaque erythema and will result in minimal hyperpigmentation.
Subjects will undergo Excimer treatment twice a week until they reach a PASI 75 improvement, or until they reach the maximum of 20 total treatments. A blood draw to assess serum inflammatory markers will be performed at the screening visit and final visit. Chromameter assessment, photographs, PASI and PGA (Physician Global Assessment) will be performed throughout the study to monitor psoriasis improvement, hyperpigmentation and erythema.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Excimer laser irradiation twice a week for up to 20 treatments.
University Hospitals Cleveland Medical Center (Concord Site)
Concord, Ohio, United States
Change in serum inflammatory markers
Change in CRP, MPO, S100 and Resistin levels from screening to final visit.
Time frame: 23 visits (~12 weeks)
Objective measure of hyperpigmentation
Chromameter Assessment to measure hyperpigmentation. L\* values are measured with a chromameter. A lower L\* means more hyperpigmentation.
Time frame: 23 visits (~12 weeks)
Objective measure of erythema
Chromameter Assessment to measure erythema. a\* values are measured with a chromameter. A higher a\* means more erythema.
Time frame: 23 visits (~12 weeks)
Improvement in Psoriasis based on PASI assessment
PASI will be performed throughout the study to assess response to treatment.
Time frame: 23 visits (~12 weeks)
Improvement in psoriasis based on PGA
PGA (Physician Global Assessment) will be performed throughout the study to assess response to treatment.
Time frame: 23 visits (~12 weeks)
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