Investigation of Gait Parameters in Health and Neurological Disease Under Varying Locomotor Conditions

Inclusion Criteria: Patients: * age 18 - 80 * written, informed consent * one of the following established diagnoses: unilateral stroke affecting motor system, Parkinson syndrome, cerebellar disease, vestibular dysfunction, spinal cord injury, multiple sclerosis * Brain and whole spine T1, T2 \& FLAIR magnetic resonance imaging performed within the last four months and available for study purposes or no contraindications to performing these scans Healthy subjects: * age 18 - 80 * written informed consent Exclusion Criteria: Patients: * Colour-blindness * Known to be pregnant or breastfeeding * Body mass index (weight in kg/height in metres squared) \>40 Unable to walk 50m within 6 minutes (with or without walking aids) Inability to undertake any component of the trial protocol * Terminal diagnosis with life expectancy less than six months * Cognitive disturbance defined as MMSE \< 25 Clinically significant comorbidities such as severe cardiovascular, pulmonary or malignant disease Healthy subjects: * Colour-blindness * Known to be pregnant or breastfeeding * Body mass index (weight in kg/height in metres squared) \>40 Unable to walk 50m within 6 minutes * Reliance on walking aids / prostheses for mobilisation * Significant neurological or orthopaedic diagnosis with potential impact on gait // Previous operations on the lower limbs or spine with potential impact on gait Inability to undertake any component of the trial protocol Clinically significant conditions such as severe cardiovascular, pulmonary or malignant disease