Safety and Efficacy Study of Regulatory T Cell Therapy in Liver Transplant Patients

Inclusion Criteria: * Able to give informed consent * adult patients with end-stage liver disease listed for primary liver transplant; * calculated MELD score ≤ 25 at time of transplantation Exclusion Criteria: * HIV or RNA-positive Hepatitis C Virus infection; * autoimmune liver disease * previous organ transplant * Ebstein Virus and/or Cytomegalovirus sero-negativity * chronic use of systemic immunosuppressants * hepatocellular carcinoma outside Milano criteria * leukocytes \<1.5x10\^9/L and/or platelets \<50x10\^9/L.