Effect of Sorting of Apoptotic Spermatozoa on the Outcome of Assisted Reproduction

Inclusion Criteria: * infertile couples needing treatment with ICSI * male infertility as defined by the WHO 2010 criteria * age of the treated women should be between 22 and 39 years of age. * normal ovarian reserve, as defined by basal FSH-concentration below 10 IU/l and AMH-concentration above 10 pmol/l. * signed consent form. Exclusion Criteria: * normal male infertility, as defined by the WHO 2010 criteria * age of the treated women below 22 years and above 39 years * reduced ovarian reserve, as defined by an elevated basal FSH-concentration or reduced AMH-concentration. * Not more than two preceding unsuccessfull treatments with ICSI * Severe disease of the male or female partner, such as HIV, hepatitis, or psychiatric illness. * Participation in another study. * lack of a signed consent form.