Accuracy of CNAP PPV Under General Anaesthesia

University Hospital Schleswig-Holstein54 enrolled

Overview

Noninvasive pulse pressure variation for the guidance of perioperative fluid therapy is compared with the gold standard of invasive measurements. Cardiac output is derived by the PICCO monitor. Hypothesis: Noninvasive CNAP PPV predicts fluid responsiveness. A grey zone for the prediction of fluid responsiveness will be defined.

Accuracy of PPV measured by two devices,PICCO and CNAP, is compared with the manually calculated PPV from the arterial line waveform. Established tests like passive leg raising and end-expiratory occlusion are used for prediction of fluid responsiveness. Intraoperative events like volume challenge are monitored.

Study Type

OBSERVATIONAL

Enrollment

Conditions

General Anaesthesia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * major surgery * need for invasive arterial measurements Exclusion Criteria: * age under 18 * cardiac dysrhythmia * vascular pathology at punction site

Locations (1)

University Hospital, Schleswig-Holstein. Departement of Anaesthesiology and Intensive Care Medicine

Kiel, Germany

Outcomes

Primary Outcomes

Cardiac output

Improvement of cardiac output dependent on PPV before volume challenge

Time frame: 1, 2, 5, 10, 15 and 20 minutes after volume challange and

Data from ClinicalTrials.gov

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