Immune Response to Hepatitis B Virus Booster Vaccination After 20-23 Years

Seoul National University Hospital9 enrolled

Overview

This study will evaluate the humoral and cellular immune responses to a hepatitis B vaccine booster in healthy adults which received a full course of neonatal hepatitis B vaccination 20-23 years ago.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Hepatitis B Vaccination

Interventions

HBV booster vaccination 1doseBIOLOGICAL

Eligibility

Sex: ALLMin age: 20 YearsMax age: 25 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy adults 20-25 years old Exclusion Criteria: * Hepatitis B surface antigen (+) * Hepatitis B core antibody (+) * any history of liver disorders including hepatitis * HIV Ag or Ab(+)

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

change of HBsAb titer

Time frame: 28 days after HBV booster vaccination

Secondary Outcomes

HBsAg-specific cell mediated immunity

Time frame: 28 days after HBV booster vaccination

Data from ClinicalTrials.gov

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