Benign Prostatic Hyperplasia and Prostate Size Greater Than 90 Grams

Inclusion Criteria: * Patient is aged 50-85 years * Patient has signed informed consent * Patient has experienced lower urinary tract symptoms (LUTS) for at least 1 year prior to study enrollment * Patient has a prostate size larger than 90g as measured by transrectal ultrasound (TRUS) * Patient has an IPSS score greater than or equal to 13 * Patient has a peak urine flow rate \< 12 mL/sec * Patient either: * Refuses surgical treatment * Is considered high risk for surgical treatment * Patient is either: * Refractory to medical treatment * Contraindicated for medical treatment * Patient must meet ONE of the following criteria: * Baseline PSA ≤ 2.5ng/mL * Baseline PSA \> 2.5 ng/mL and ≤ 10 ng/mL AND free PSA ≥ 25% of total PSA (no biopsy required) * Baseline PSA \> 2.5 ng/mL and ≤ 10 ng/mL AND free PSA \< 25% of total PSA AND negative prostate biopsy result (minimum of 12 core biopsy) within 12 months * Baseline PSA \>10 ng/mL AND negative prostate biopsy result (minimum of 12 core biopsy) within 12 months Exclusion Criteria: * History of prostate or bladder cancer, or currently being evaluated for cancer * History of prostate or bladder cancer, or currently being evaluated for cancer * Patient has taken alpha blockers within 4 weeks of screening * Patient has experienced an irregular voiding pattern despite medical management with a stable 5-alpha reductase inhibitor dosage for 3 months or longer * History of open prostate surgery, radiofrequency, or microwave therapy * Previous open bladder or rectosigmoid colon surgery * TURP within the last two years * Patient has nodularity or induration detected upon digital rectal examination (DRE) * Neurogenic bladder or other neurological disorder impacting bladder function * Urethral stricture, bladder neck contracture, other potentially confounding bladder pathology, bladder disease, or confounding urethral pathology * Acute urinary retention requiring an indwelling catheter * Bladder atonia * Active prostatitis or urinary tract infection * Cystolithiasis within the past 3 months * Serum creatinine \>1.7mg/dL * Coagulation disturbances not normalized by medical treatment * Iodinated contrast allergy not controlled with 24-hour steroid preparation * History of gelatin allergy * History of pelvic irradiation * History of severe peripheral vascular disease or known major iliac arterial occlusive disease * History of smoking greater than 30 pack-years * Interest in future fertility * Significant cardiac or respiratory disease that the Investigator believes puts the patient at risk for a complication during the procedure * Any other risks or factors that the Investigator believes puts the patient at risk for a complication during the procedure