Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID)

Inclusion Criteria: * Open-angle glaucoma or ocular Hypertension * Currently treated with Latanoprost for min of 6 weeks * Male or Female 18 yrs and older * Best Corrected Visual Acuity 20/100 or better in both eyes * Pachymetry \>470 and \< 640 * Women of childbearing potential must have a negative urine pregnancy test at the screening/baseline visit * Patient willing and capable of providing informed consent Exclusion Criteria: * C/D \> 0.8 * Visual field loss, which in the opinion of the investigator is functionally significant * Current use of ocular steroids * Concurrent significant active ocular disease History (within 3 months prior to Screening) of ocular laser, intraocular, filtering or refractive surgery or planned ocular surgery of any kind during study participation * Change within prior 30 days or anticipated change in any systemic medication that is known to affect IOP * Uncontrolled systemic disease * Significant ocular hyperemia at baseline * Prior glaucoma procedure within 3 months * Females who are pregnant, nursing, or planning a pregnancy or who are of childbearing potential and not using a reliable method of contraception * Known allergy or sensitivity to any study medication * Asthma or any other known medical condition that the investigator feels would put patient at increased risk from any of the study medications * Current enrollment in an investigational drug or device study or participation in such a study within 30 days prior to Screening