The purpose of this study is to determine whether repetitive Transcranial Magnetic Stimulation (rTMS) is effective in the cognitive rehabilitation of patients with diffuse axonal injury(DAI) after Traumatic Brain Injury(TBI).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
30
The patients will undergo 10 sessions (2,000 pulses each, lasting 20 minutes) of repetitive transcranial magnetic stimulation over the left dorsolateral prefrontal cortex with the following parameters: 10Hz, 50 trains (40 pulses on each train), biphasic wave, 25 seconds between the trains.
The patients assigned to this group will undergo 10 sessions of rTMS but with an inactive coil, which will not generate electromagnetic pulses.
Clinics Hospital - University of Sao Paulo Medical School
São Paulo, São Paulo, Brazil
Evidence of improvement on Attentional processes measured by cognitive evaluation (Trail Making Test parts A and B; Stroop Test - Victoria Version; Symbol Digit Test)
Time frame: One week and three months after rTMS.
Evidence of improvement on Executive Function processes measured by cognitive evaluation.
Time frame: one week and 3 months.
Evidence of improvement on Motor Coordination measured by cognitive evaluation.
Time frame: one week and three months.
Changes in cortical excitability measured by single and paired-pulse TMS
Time frame: one week and three months.
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