Remote Ischemia Precondition (RIPC) for Hepatic Protection in Patients Undergoing Hepatectomy

Eastern Hepatobiliary Surgery Hospital100 enrolled

Overview

Remote ischemia precondition could protect the liver from ischemia reperfusion injury in patients undergoing hepatectomy.

Remote ischemia precondition (RIPC) had been proofed beneficial to ischemia reperfusion injury of heart, kidney, liver, brain and spinal cord in experimentation on animals. And the clinical studies of RIPC were mainly focused on heart, RIPC's protection effect on hepatic ischemia reperfusion injury in patients undergoing hepatectomy still remains unknown, So we designed this study to demonstrate the hypotheses.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

100

Conditions

Liver Neoplasms

Interventions

Remote ischemia preconditionOTHER

Three cycles of 5-min ischemia/5-min reperfusion induced by a blood pressure cuff placed on the right upper arm served as RIPC stimulus.

None remote ischemia preconditionOTHER

Placed an uninflated cuff on the right upper arm for 30 min.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * No other main organ diseases, American society of Anesthesiologists (ASA) classification Ⅰ-Ⅱ grade * Selective hepatectomy, one time hepatic portal occlusion * Child-Pugh A Exclusion Criteria: * Peripheral vessels diseases * Not the same surgical procedure as expected * Administered anti-inflammatory drugs as glucocorticoid etc * Diagnosed of diabetes * History of liver surgery * History of hepatic interventional therapy, radiofrequency therapy,radiotherapy and chemotherapy * Refuse to join the research * Patients with psychopathy * Acute infection need antibiotic therapy * Hepatic artery or portal vein embolism

Locations (1)

Eastern Hepatobiliary Surgery Hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

survival rate

Time frame: 30 days postoperatively

Secondary Outcomes

alanine aminotransferase (ALT) level in patients' blood

Examine the patients's blood sample for ALT level at 1 day postoperatively

Time frame: 1 day postoperatively

aspartic transaminase (AST) level in patients' blood

Examine the patients's blood sample for AST level at 1 day postoperatively

Time frame: 1 day postoperatively

alanine aminotransferase (ALT) level in patients' blood

Examine the patients's blood sample for ALT level at 3 days postoperatively

Time frame: 3 days postoperatively

aspartic transaminase (AST) level in patients' blood

Examine the patients's blood sample for AST level at 3 days postoperatively

Time frame: 3 days postoperatively

alanine aminotransferase (ALT) level in patients' blood

Examine the patients's blood sample for ALT level at 7 days postoperatively

Time frame: 7 days postoperatively

aspartic transaminase (AST) level in patients' blood

Examine the patients's blood sample for AST level at 7 days postoperatively

Time frame: 7 days postoperatively

complications

Number of participants with adverse events within 30 days postoperatively

Time frame: 30 days postoperatively

Central Contacts

Weifeng Yu, professor

CONTACT

86-10-81875231 ywf808@sohu.com

Data from ClinicalTrials.gov

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