Probiotics modulate the gut microflora and immune status in CRC,which can reduce the side effects of chemotherapy such as diarrhea,infection,neutropenia etc.
Chemotherapy destroys the intestinal mucosal barrier, affects intestinal flora, causing bacterial translocation, infection and other complications; Probiotics may restore the intestinal immunity, mucosal barrier, and nutrient absorption.The adverse effects of chemotherapy and the malnutrition status may be relieved via probiotic administration.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Enrollment
30
Microbial composition using probiotic
microbiota modulation using placebo
Department of Gastroenterology,Qilu Hospital,Shandong University
Jinan, Shandong, China
RECRUITINGComposition of Microorganisms in stool after probiotic intervention
Primary coordination of fecal samples' 16s rDNA (ribosomal DNA) will be compared between two Groups using Braycurtis distance based Primary coordination analysis (PCoA).
Time frame: 5 months
Short-chain fatty acids in feces of patients after chemotherapy
The total concentration of Short-chain fatty acids in the in feces of patients after chemotherapy.
Time frame: 5 months
Frequency and severity of Adverse effects during Chemotherapy
Adverse effects includes vomiting, nausea, diarrhea and abdominal pain.
Time frame: 5 months
The observed changes in immune status after chemotherapy
Immune status indexes include percentage of Neutrophils, total lymphocytes, lymphocyte subgroups, plasma immunoglobulin level, CRP (C reactive protein).
Time frame: 5 month
The observed changes in nutritional status after chemotherapy
Nutritional status indexes include BMI, percentage of body weight changes, plasma albumin and prealbumin.
Time frame: 5 months
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