Improving Negative Symptoms of Psychosis In Real-world Environments

University of California, San Diego64 enrolled

Overview

This study will compare Cognitive Behavioral Social Skills Training-Compensatory Cognitive Training (CBSST-CCT) to a goal-focused supportive contact group to see which intervention better improves symptoms and functioning in people with schizophrenia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Schizophrenia

Interventions

CBSST-CCTBEHAVIORAL

Goal focused supportive contactBEHAVIORAL

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: MUST BE A RESIDENT OF BROADWAY HOME, SAN DIEGO, OR A SERVICE USER OF THE MEETING PLACE, ARETA CROWELL, OR PROJECT ENABLE. 1. Voluntary informed consent to participate 2. Age 18 to 65 3. DSM-IV diagnosis of schizophrenia or schizoaffective disorder based on MINI/SCID 4. Moderate-to-severe negative symptoms on the Clinical Assessment Interview for Negative Symptoms (CAINS total score \>19) 5. ≥ 6th grade reading level on the Wide Range Achievement Test-4 Reading subtest (needed for reading treatment manual) 6. Stable on medications; no changes within 3 months prior to enrollment Exclusion Criteria: 1. Prior CBT, SST, or CCT in the past 5 years 2. Severe positive symptoms on the Positive and Negative Syndrome Scale (PANSS Delusions, Disorganization, Hallucinations, or Suspiciousness \>5) 3. Severe depression on the Calgary Depression Scale for Schizophrenia (CDSS \>8) 4. Ocular damage/disease/surgery/medications that affect pupil dilation 5. DSM-IV alcohol or substance dependence diagnosis in past 6 months based on the MINI or SCID 6. Level of care required interferes with outpatient therapy (e.g., hospitalized; severe medical illness) .

Locations (1)

UCSD

La Jolla, California, United States

Outcomes

Primary Outcomes

Clinical Assessment Interview for Negative Symptoms (CAINS)

Change in negative symptom severity at 12.5 weeks. Scores range from 0-52; higher values indicate greater severity.