The overall objective with the study was to contribute to the scientific basis for dietary and life strategies, policies and dietary guidelines to infants and young children in Denmark and with special focus on prevention of obesity and diet related chronic diseases such as type 2 diabetes, ischemic heart disease and osteoporosis.
The SKOT I study is a prospective cohort study monitoring healthy young children from 9 to 36 months of age. In 2007, 2211 families from Copenhagen were randomly selected through the National Civil Registry and invited to participate in the study by letter. The participants were invited to three examinations at 9 months ±2 weeks, 18 months ±4 weeks and 36 months ±3 months. A total of 330 children are included in the study, where 312 have completed the 9 months examination, 291 completed the 18 months examination and 263 completed the 3-year examination. All examinations took place at Department of Nutrition, Exercise and Sports, Frederiksberg Denmark. The examinations involved collecting a broad spectrum of data. Following data were collected: anthropometry (weight, height, age- and sex-specific Z-scores for body composition, triceps and subscapularis skinfolds), background interview (concerning e.g. infant feeding, household income, the parent's educational level, allergy and chronic diseases), blood pressure (systolic, diastolic and mean arterial pressure), faeces- and urine sample, blood samples (9 and 36 months), Bio impedance analysis (36 months), 7 day diet registration, general questionaire (concerning e.g. sleep, daycare, attendance and use of screen devices), psychomotor questionnaire (motoric development), 7 day physical activity monitoring and dual energy x-ray absorptiometry scan (36 months).
Study Type
OBSERVATIONAL
Enrollment
263
Department of Human Nutrition, Faculty of Sciences, University of Copenhagen
Frederiksberg, Denmark
Change in anthropometric measurements in periods of early childhood.
Composite outcome consisting of body weight, height, body mass index (BMI) and BMI z-scores, waist-, upper arm- and head circumference, skinfold thickness measured at subscapularis and triceps.
Time frame: 9, 18 and 36 months of age
Body composition in early childhood
Body composition is measures by Dual-energy X-ray Absorptiometry and bio impedance. Fat mass, fat mass index (kg/m2), fat free mass index (kg/m2) are calculated.
Time frame: 36 months of age
Metabolic syndrome score in early life
Composite outcome consisting of triglycerides, high lipoprotein (HDL) and glucose measured in plasma/serum, waist circumference and blood pressure.
Time frame: 9 and 36 months of age
Diet in periods of early life
The diet is recorded using self-reported 7-day record questionnaire.
Time frame: 9, 18 and 36 months of age
Breastfeeding duration in infancy and early childhood
Questionnaire used for assessment of exclusive and partially breastfeeding.
Time frame: 9, 18 and 36 months of age
Insulin like growth factor at 9 and 36 months of age
Insulin like growth factor-1 and insulin like growth factor binding protein-3 concentrations in plasma.
Time frame: 9 and 36 months of age
Physical activity, sedentary behavior and sleep in early childhood
Physical activity and sedentary behavior measured by ActiGrafph GT3X accelerometer, recording for 24 hours in 7 days at 36 months of age. Information on outdoor activity, sedentary behavior and night sleep are collected through questionnaires at 9, 18 and 36 months of age.
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Time frame: 9, 18 and 36 months of age
Bone mass in 3-year-old children
Bone mass is measured by Dual-energy X-ray Absorptiometry
Time frame: 36 months of age
Vitamin D status in infancy
25-hydroxyvitamin D concentrations are analysed in blood samples at 9 months of age.
Time frame: 9 months of age
Allergy and chronic diseases
Assessment of diseases by questionnaires
Time frame: 9 and 36 months of age
Appetite hormones in infancy
Leptin and adiponectin concentrations measured from blood samples
Time frame: 9 months of age
Change in gut microbiota
Microbiota in the faeces analysed using polymerase chain reaction (PCR)
Time frame: 9, 18 and 36 months of age
Achievement of milestones
Achievement of age-specific milestones by questionnaires; WHO questionnaires at 9 and 36 months of age and Ages \& Stages Questionnaires (ASQ) at 36 months of age
Time frame: 9 and 36 months of age
Metabolomics in the urine
Metabolomics analysed using urine samples.
Time frame: 9, 18 and 36 months of age