To assess the amount of BIBR 953 ZW in urine of 50 mg of BIBR 1048 bid over three days each administered as four experimental capsule formulations relative to drinking solution with and without coadministration of 40 mg pantoprazole.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
16
Ae 0-12h: amount of drug (total BIBR 953 ZW) excreted into urine during all individual dosing intervals
Time frame: up to 3 days after each administration
Area under the concentration time course at steady state (AUCss)
Time frame: 0.5, 1, 1.5, 2, 4, 6, 8 and 12 hours after study drug administration on day 3 of period 2
Occurence of adverse events
Time frame: up to 40 days
Maximum plasma concentration at steady state (Cmax,ss)
Time frame: 0.5, 1, 1.5, 2, 4, 6, 8 and 12 hours after study drug administration on day 3 of period 2
Time at which maximum plasma concentration occurs after dosing during steady state (tmax,ss)
Time frame: 0.5, 1, 1.5, 2, 4, 6, 8 and 12 hours after study drug administration on day 3 of period 2
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