this study aim to investigate the: * association of RAAS polymorphisms and AHF * association of MMP 3 and 12 polymorphisms and AHF
Heart failure can be defined as a complex clinical syndrome that results from any structural or functional disorder of the heart, with impairment of ability to fill the ventricles or eject blood. The main event of the IC is dyspnea and fatigue, which limit exercise tolerance and induces water retention. The renin angiotensin aldosterone system governs the salt and water homeostasis in the body. Renin is a proteolytic enzyme secreted by the juxtaglomerular apparatus of the kidney (area near the glomeruli). Renin has no direct action on the organism, but that is part of the renin-angiotensin system or the renin-angiotensin-aldosterone system is known. To date, few published studies have examined the association between the polymorphism AGT M235T \* and cardiac dysfunction; and available results are contradictory. What is not known yet is the ratio of this polymorphism with the prognosis of heart failure.
Study Type
OBSERVATIONAL
Enrollment
300
Nouira Samir
Monastir, Emergency Department Monastir, Tunisia 5000, Tunisia
mortality RAAS
the association between RAAS genes polymorphisms and mortality at one year average
Time frame: one year
association between RAAS polymorphism and AHF
the association between the diagnosis of AHF (based on clinical, BNP, and echocardiographic finds) and the RAAS genes polymorphism is studied at patient admission for acute dyspnea.
Time frame: at admission (an average of 1 day)
association between MMP polymorphism and AHF
the association between the diagnosis of AHF (based on clinical, BNP, and echocardiographic finds) and the MMP genes polymorphism is studied at patient admission for acute dyspnea.
Time frame: at admission (average of 1 day)
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