The purpose of this research study is to determine how cell changes during endotracheal intubation and artificial lung ventilation affect lung inflammation. Patients will undergo placement of an endotracheal tube (ETT) as standard of care. Tracheal (windpipe) lavage will be obtained each day for up to 72 hours. Lung samples or fiberoptic (lung) samples will be collected at the same time intervals when possible and if they are done as standard of care. Blood samples will be obtained simultaneous with the collection of the trachael (windpipe) specimens.
Study Type
OBSERVATIONAL
Enrollment
8
Washington University School of Medicine
St Louis, Missouri, United States
Neutrophil changes
Identifying indicators of neutrophil inflammatory changes that occur during 72 hours of tracheal injury secondary to endotracheal intubation.
Time frame: 72 hours
analyze neutrophil activation
Analyze neutrophil activation in the distal airways in biological samples obtained simultaneously with tracheal samples and to correlate them with the development of lung inflammation.
Time frame: 72 hours
correlate tracheal and lung neutrophil activation
Correlate tracheal and lung neutrophil activation with development of pneumonia in ICU patients requiring mechanical ventilation.
Time frame: 72 hours
determine the impact of airway (tracheal, lung) inflammation
Determine the impact of airway (tracheal, lung) inflammation as determined by neutrophil activation on the length of stay (LOS), discharge, and readmission to ICU in the first 90 days post airway inflammation (VAP) diagnosis.
Time frame: 72 hours
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